Overview:
A biopsy is a procedure where a small part of pathological tissue is removed through a Minimally Invasive Technique for diagnosis and examination. This procedure is indicated in patients suspected of Spinal Infections, Tuberculosis, Spinal Tumours or when the diagnosis is in doubt]. A few investigations are usually asked for before the procedure.
CT guided Biopsy: In some patients, surgeon may recommend a CT Guided biopsy. The procedure is essentially similar except that it is done under CT guidance rather than X-ray guidance. This is advised when the pathology is better seen on CT or is very close to important neuro vascular structures.

Disclaimer: The description of procedure is how usually a surgery is done. During the procedure, based on intra operative encounters which varies from patient to patient different steps may be performed.